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Dimethylsulfoxide (DMSO) 99,5% 1lt - Dimethylsulfoxide (DMSO) 99,5% 1lt

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Dimethylsulfoxide (DMSO) 99,5% 1lt - Dimethylsulfoxide (DMSO) 99,5% 1lt Dimethylsulfoxide (DMSO) 99,5% 1lt - Dimethylsulfoxide (DMSO) 99,5% 1lt
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Dimethylsulfoxide (DMSO) 99,5% 1lt - Dimethylsulfoxide (DMSO) 99,5% 1lt Dimethylsulfoxide (DMSO) 99,5% 1lt - Dimethylsulfoxide (DMSO) 99,5% 1lt
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Dimethylsulfoxide (DMSO) 99,5% 1lt - Dimethylsulfoxide (DMSO) 99,5% 1lt

Dimethylsulfoxide (DMSO) 99,5% 1lt - Dimethylsulfoxide (DMSO) 99,5% 1lt
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Home Κατάστημα Laboratory Equipment Chemical Reagents Organic Compounds Dimethylsulfoxide (DMSO) 99,5% 1lt
Dimethylsulfoxide (DMSO) 99,5% 1lt - Dimethylsulfoxide (DMSO) 99,5% 1lt
Dimethylsulfoxide (DMSO) 99,5% 2,5lt €92,74 €115,00 με ΦΠΑ
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Dimethylsulfoxide (DMSO) 99,5% 1lt - Dimethylsulfoxide (DMSO) 99,5% 1lt
Calcium Carbonate (powder) (500gr) €10,40 €12,90 με ΦΠΑ

Dimethylsulfoxide (DMSO) 99,5% 1lt

€64,52 €80,00 με ΦΠΑ

DMSO 99,5% 1lt
Dimethyl Sulfoxide, Methylsulfinylmethane, Methyl sulfoxide
C2H6OS
M.W: 78.13 g·mol−1
Cas Number: 67-68-5
https://pubchem.ncbi.nlm.nih.gov/compound/Dimethyl-sulfoxide

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SKU: 330103 Categories: Organic Compounds, Organic Compounds Tag: Solvents
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  • Description
Description

Dimethylsulfoxide (DMSO) 99,5% 1lt

Dimethyl sulfoxide (DMSO) is an organosulfur compound with the formula (CH3)2SO. This colorless liquid is an important polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water. It has a relatively high boiling point. DMSO has the unusual property that many individuals perceive a garlic-like taste in the mouth after contact with the skin.

Properties

Chemical Formula: C2H6OS

Molecular weght: 78.13 g·mol−1

Density: 1.1004 g⋅cm−3

Boiling point: 189 °C

Melting point: 19 °C

Solubility in water: Insolube

Appearance: colourless liquid

Chemical Structure

Dimethylsulfoxide (DMSO) 99,5% 1lt - Dimethylsulfoxide (DMSO) 99,5% 1lt

Safety

Dimethylsulfoxide (DMSO) 99,5% 1lt - Dimethylsulfoxide (DMSO) 99,5% 1lt

Irritant

Description

DMSO is a polar aprotic solvent and is less toxic than other members of this class, such as dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, and HMPA. DMSO is frequently used as a solvent for chemical reactions involving salts, most notably Finkelstein reactions and other nucleophilic substitutions. It is also extensively used as an extractant in biochemistry and cell biology. Because DMSO is only weakly acidic, it tolerates relatively strong bases and as such has been extensively used in the study of carbanions. A set of non-aqueous pKa values (C-H, O-H, S-H and N-H acidities) for thousands of organic compounds have been determined in DMSO solution.

Because of its high boiling point, 189 °C (372 °F), DMSO evaporates slowly at normal atmospheric pressure. Samples dissolved in DMSO cannot be as easily recovered compared to other solvents, as it is very difficult to remove all traces of DMSO by conventional rotary evaporation. One technique to fully recover samples is removal of the organic solvent by evaporation followed by addition of water (to dissolve DMSO) and cryodesiccation to remove both DMSO and water. Reactions conducted in DMSO are often diluted with water to precipitate or phase-separate products. The relatively high freezing point of DMSO, 18.5 °C (65.3 °F), means that at, or just below, room temperature it is a solid, which can limit its utility in some chemical processes (e.g. crystallization with cooling).

In its deuterated form (DMSO-d6), it is a useful solvent for NMR spectroscopy, again due to its ability to dissolve a wide range of analytes, the simplicity of its own spectrum, and its suitability for high-temperature NMR spectroscopic studies. Disadvantages to the use of DMSO-d6 are its high viscosity, which broadens signals, and its hygroscopicity, which leads to an overwhelming H2O resonance in the 1H-NMR spectrum. It is often mixed with CDCl3 or CD2Cl2 for lower viscosity and melting points.

DMSO is finding increased use in manufacturing processes to produce microelectronic devices. It is widely used to strip photoresist in TFT-LCD ‘flat panel’ displays and advanced packaging applications (such as wafer-level packaging / solder bump patterning). It also used in biopreservation, especially stem cell banking. DMSO is an effective paint stripper, being safer than many of the others such as nitromethane and dichloromethane.

Because of its ability to dissolve many kinds of compounds, DMSO plays a role in sample management and high-throughput screening operations in drug design.

Biology
DMSO is used in polymerase chain reaction (PCR) to inhibit secondary structures in the DNA template or the DNA primers. It is added to the PCR mix before reacting, where it interferes with the self-complementarity of the DNA, minimizing interfering reactions.

DMSO in a PCR reaction is applicable for supercoiled plasmids (to relax before amplification) or DNA templates with high GC-content (to decrease thermostability). For example, 10% final concentration of DMSO in the PCR mixture with Phusion decreases primer annealing temperature (i.e. primer melting temperature) by 5.5–6.0 °C (9.9–10.8 °F).

It is well known as a reversible cell cycle arrester at phase G1 of human lymphoid cells.

DMSO may also be used as a cryoprotectant, added to cell media to reduce ice formation and thereby prevent cell death during the freezing process. Approximately 10% may be used with a slow-freeze method, and the cells may be frozen at −80 °C (−112 °F) or stored in liquid nitrogen safely.

DMSO has been used as a co-solvent to assist absorption of the flavonol glycoside Icariin into the C. elegans nematode worm.

In cell culture, DMSO is used to induce differentiation of P19 embryonic carcinoma cells into cardiomyocytes and skeletal muscle cells.

Medicine
Use of DMSO in medicine dates from around 1963, when an Oregon Health & Science University Medical School team, headed by Stanley Jacob, discovered it could penetrate the skin and other membranes without damaging them and could carry other compounds into a biological system. In medicine, DMSO is predominantly used as a topical analgesic, a vehicle for topical application of pharmaceuticals, as an anti-inflammatory, and an antioxidant. Because DMSO increases the rate of absorption of some compounds through biological tissues, including skin, it is used in some transdermal drug delivery systems. Its effect may be enhanced with the addition of EDTA. It is frequently compounded with antifungal medications, enabling them to penetrate not just skin but also toenails and fingernails.

DMSO has been examined for the treatment of numerous conditions and ailments, but the U.S. Food and Drug Administration (FDA) has approved its use only for the symptomatic relief of patients with interstitial cystitis. A 1978 study concluded that DMSO brought significant relief to the majority of the 213 patients with inflammatory genitour

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